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Curr Opin Biotechnol. 1992 Oct;3(5):560-5.

Protein processing within the secretory pathway.

Author information

1
Genetics Institute, Cambridge, Massachusetts.

Abstract

Endoproteolytic cleavage of hormone and neuropeptide precursors, as well as many complex proteins, such as coagulation factors and viral glycoproteins, is a key process in the generation of bioactive polypeptides. These cleavages typically occur at the dibasic amino acid residues Lys-Arg or Arg-Arg. The enzymes responsible for the processing belong to a newly discovered family of serine proteases related to the bacterial subtilisins. These include PACE (furin), PC1/PC3, PC2 and PACE4, which have all been characterized functionally and structurally.

PMID:
1368940
DOI:
10.1016/0958-1669(92)90086-x
[Indexed for MEDLINE]

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