Antitussive activity of Abies webbiana Lindl. leaf extract against sulphur dioxide-induced cough reflex in mice

Phytother Res. 2003 Sep;17(8):930-2. doi: 10.1002/ptr.1263.

Abstract

The methanol extract of A. webbiana Lindl was evaluated for its effect on a cough model induced by sulphur dioxide gas in mice. When administered orally it exhibited significant antitussive activity compared with the control in a dose dependent manner. The antitussive activity of the extract was compared with that of codeine phosphate, a prototype antitussive agent. The A. webbiana leaf extract (400 and 600 mg/kg) showed maximum inhibition of cough frequency by 71.69% and 78.67%, respectively, when compared with the control group and was comparable in effect to codeine phosphate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abies*
  • Administration, Oral
  • Animals
  • Antitussive Agents / administration & dosage
  • Antitussive Agents / pharmacology*
  • Antitussive Agents / therapeutic use
  • Cough / chemically induced
  • Cough / prevention & control*
  • Dose-Response Relationship, Drug
  • Female
  • Male
  • Mice
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Plant Leaves
  • Sulfur Dioxide

Substances

  • Antitussive Agents
  • Plant Extracts
  • Sulfur Dioxide