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Ann Hematol. 2003 Nov;82(11):696-8. Epub 2003 Sep 9.

Triplication (/alphaalphaalpha anti3.7) or deletion (-alpha3.7/) association in Argentinian beta-thalassemic carriers.

Author information

1
Cátedra de Hematología, Departamento de Bioquímica Clínica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario Santa Fe, Argentina. ibragos@fbioyf.unr.edu.ar

Abstract

Prevalence of alpha gene triplication or deletion in beta-thalassemia carriers was studied in 109 unrelated individuals in Rosario, Argentina. In different populations -alpha(3.7) allele presents a higher prevalence than alphaalphaalpha(anti3.7); thus, alpha-thalassemia associated with beta-thalassemia is more frequently observed. Nevertheless, this event was detected in only one case (0.9%), while the association with alpha triplication was present in two subjects (1.8%).

PMID:
13680176
DOI:
10.1007/s00277-003-0738-6
[Indexed for MEDLINE]

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