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Mol Biotechnol. 2003 Sep;25(1):53-61.

Mimotopes of tumor-associated T-cell epitopes for cancer vaccines determined with combinatorial peptide libraries.

Author information

1
Department of Dermatology and Allergy, Medical Faculty Charité, Humboldt University, Schumannstrasse 20/21, 10117, Berlin, Germany.

Abstract

Cytotoxic T-cells are the most important effector cells in immune responses against tumors. The identification of tumor-associated epitopes for these cells, therefore, has become a key aspect of the development of cancer vaccines. Here, we describe a new approach to the determination of tumor-associated T-cell epitopes which employs combinatorial peptide libraries with singly defined sequence positions in a randomized context. The analysis of the responses of a T-cell clone to these libraries yields the amino acid constituents of the epitope which can be combined to obtain mimotopes that are suitable as vaccine antigens for the induction of tumor-specific responses.

PMID:
13679635
DOI:
10.1385/MB:25:1:53
[Indexed for MEDLINE]
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