Format

Send to

Choose Destination
Trends Biochem Sci. 2003 Sep;28(9):473-7.

New types of conserved sequence domains in DNA-binding regions of homing endonucleases.

Author information

1
Molecular Genetics Department, Weizmann Institute of Science, PO Box 26, Rehovot 76100, Israel.

Abstract

We have identified four new types of short conserved sequence domains in homing endonucleases and related proteins. These domains are modular, appearing in various combinations. One domain includes a motif known by structure as a novel sequence-specific DNA-binding helix. Sequence similarity shows two other domains to be new types of helix-turn-helix DNA-binding domains. We term the new domains nuclease-associated modular DNA-binding domains (NUMODs).

PMID:
13678957
DOI:
10.1016/S0968-0004(03)00170-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center