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Appl Microbiol Biotechnol. 1990 Sep;33(6):709-11.

The role of monic acid A in pseudomonic acid A biosynthesis in Pseudomonas fluorescens.

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Department of Biochemistry, Imperial College, London, UK.


The putative role of monic acid A as a biosynthetic intermediate of the antibiotic pseudomonic acid A, providing a C17 moiety requiring only esterification with a C9 fatty acid, has been tested by administration of [14C]monic acid A early in the pseudomonic acid A idiophase of a Pseudomonas fluorescens fermentation. [14C]Monic acid A was not taken up by the cells and the pseudomonic acid A subsequently accumulated was not radiolabelled. Experimental demonstration of the biosynthetic role of monic acid A and the potential use of monate analogues in biotransformations will require unexpectedly elaborate strategies to ensure the uptake of these compounds into bacterial protoplasts. The impermeability to monic acid A explains for the first time why it is not an antibiotic.

[Indexed for MEDLINE]

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