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JAMA. 1992 Dec 16;268(23):3328-32.

Epidemiology of invasive childhood pneumococcal infections in Israel. The Israeli Pediatric Bacteremia and Meningitis Group.

Author information

1
Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer-Sheva, Israel.

Erratum in

  • JAMA 1994 Oct 5;272(13):1006.

Abstract

OBJECTIVE:

To study the epidemiology of childhood pneumococcal invasive infections in Israel as a background for immunization programs.

DESIGN:

A 2-year (October 1988 through September 1990) prospective, nationwide surveillance of all invasive pediatric pneumococcal infections.

SETTING:

All 25 medical centers hospitalizing children in Israel, including all laboratories performing blood cultures from pediatric patients.

PATIENTS:

Infants and children aged 0 to 12 years visiting the pediatric emergency department or hospitalized in pediatric departments were included if Streptococcus pneumoniae was isolated from blood or cerebrospinal fluid.

RESULTS:

Four hundred sixty-nine invasive infections were diagnosed. Pneumonia, bacteremia without apparent focus, meningitis, and cellulitis were found in 39%, 37%, 17%, and 3%, respectively. The annual incidence was 42 per 100,000 for children younger than 5 years of age (104 per 100,000 for those < 12 months old). The two most common serotypes were 1 and 5, which are rare in Western Europe and North America. Eight groups comprised 82% of all invasive infections. Extrapolated to a population in which 100,000 live births occur yearly, the total annual hospitalizations for pneumococci infections was calculated to be 1928 days. The overall case-fatality rate was 2.2%, but it was 30% during the first month of life.

CONCLUSIONS:

Pneumococcal invasive infections are common in children in Israel and carry considerable morbidity.

PMID:
1364814
[Indexed for MEDLINE]

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