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Cancer Treat Rep. 1976 Aug;60(8):1127-39.

Pharmacology of antitumor agents from higher plants.

Abstract

Some pharmacologic properties of nine antitumor agents from higher plants are described. The agents are vincristine, vinblastine the epiodophyllotoxin derivatives VM-26 and VP-16-213, maytansine, bruceantin, thalicarpine, camptothecin, and lapachol. When sufficient information is available, the agents are discussed with regard to their antitumor activity, mechanism of action, pharmacologic disposition, structure-activity relationships, and toxicity.

PMID:
136296
[Indexed for MEDLINE]

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