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Neuroreport. 1992 Nov;3(11):1030-2.

Nitric oxide mediated formation of cyclic GMP in the olfactory system.

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University of Stuttgart-Hohenheim, Institute of Zoophysiology, Germany.


Olfactory cilia preparation from rats contain considerable activity of soluble guanylate cyclase as indicated by the formation of cyclic GMP (cGMP) upon application of nitroprusside, a nitric oxide generating agent. Stimulation of olfactory cilia with high doses of odorants elicited a delayed and sustained elevation of the cGMP-concentration. The odorant-induced cGMP-response was abolished by L-NG-nitro-arginine, a selective inhibitor of nitric oxide synthesis, as well as by haemoglobin which efficiently binds and inactivates nitric oxide. These observations suggest that the NO/cGMP cascade may plan an important role in signal processing of the olfactory system.

[Indexed for MEDLINE]

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