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J Med Genet. 1992 Dec;29(12):858-60.

Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.

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  • 1Centre Hospitalier, Rouffach, France.

Abstract

Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).

PMID:
1362221
PMCID:
PMC1016201
[PubMed - indexed for MEDLINE]
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