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Bull World Health Organ. 1958;19(5):829-43.

Preparation of purified tuberculin RT 23.


The technical procedure used in the preparation of a batch of more than 500 g of purified tuberculin (PPD) is described. This batch is designated RT 23, and it is estimated that the quantity now prepared will cover the global demand for purified tuberculin for human use for several years.RT 23 has been prepared by mixing 77 smaller lots of tuberculin selected from a total of 95 lots. The method of preparing the individual lots is described and the experimental data, i.e., the yield and the biological activity ascertained by skin tests in BCG-vaccinated guinea-pigs, are given for all lots.The possible causes of variations in the yield and biological activity of the individual lots are discussed.

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