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Eur J Pharmacol. 1992 Dec 2;224(2-3):199-202.

The NMDA receptor antagonist MK-801 prevents imipramine-induced supersensitivity to quinpirole.

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  • 1B.B. Brodie Department of Neuroscience, University of Cagliari, Italy.


Chronic treatment with imipramine enhanced the locomotor stimulant response to quinpirole (0.3 mg/kg s.c.), a dopamine D2/D3 receptor agonist. Chronic, but not acute, blockade of the NMDA receptor with the non-competitive antagonist MK-801 (0.3 mg/kg i.p.) prevented the imipramine-induced potentiation of the quinpirole effect. The results suggest that NMDA receptors play a role in the development of supersensitivity to dopamine receptor agonists produced by chronic antidepressant treatment.

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