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Immunol Today. 1992 Dec;13(12):501-7.

T cells and eosinophils in the pathogenesis of asthma.

Author information

1
Dept of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK.

Abstract

Persistent asthma is characterized by chronic inflammation of the bronchial mucosa, where T cells and eosinophils are prominent. This article summarizes the evidence that asthmatic bronchial inflammation is initiated and propagated by cytokines secreted by activated T cells and other cells, and describes how the release of specific cytokines could result in local preferential accumulation and activation of eosinophils.

PMID:
1361126
DOI:
10.1016/0167-5699(92)90026-4
[Indexed for MEDLINE]

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