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Brain Res. 1992 Oct 30;594(2):327-30.

NMDA receptors in the nucleus accumbens modulate intravenous cocaine but not heroin self-administration in the rat.

Author information

1
Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037.

Abstract

The role of endogenous glutamate neurotransmission within the nucleus accumbens in the modulation of intravenous (i.v.) cocaine and heroin self-administration in rats was analyzed. APV (2-amino-5-phosphonovaleric acid), a blocker of glutamate receptors of the N-methyl-D-aspartate (NMDA) type, was microinfused within the nucleus accumbens of the ventral striatum of rats trained to lever press for i.v. cocaine or heroin self-administration. APV, at the dose of 1.5 and 3.0 micrograms/side, reduced the rewarding value of cocaine while it left heroin self-administration unaffected. These results suggest that integrity of NMDA receptor function within the nucleus accumbens may be of importance for the maintenance of i.v. cocaine, but not heroin self-administration in rats.

PMID:
1360323
DOI:
10.1016/0006-8993(92)91145-5
[Indexed for MEDLINE]

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