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J Med Primatol. 1992 Feb-May;21(2-3):59-63.

Correlates of SIV encephalitis in rhesus monkeys.

Author information

1
Tulane Regional Primate Research Center, Tulane University, Covington, LA 70433.

Abstract

Necropsy records from 204 SIV-infected rhesus monkeys that had been inoculated with various strains of SIV and had died of SIV-related disease were reviewed. The relationship of SIV encephalitis with other parameters was evaluated. Encephalitis was associated with the presence of syncytial cells in other tissues, with persistent or early recurrent antigenemia, with a selective decrease in CD4+CD29+ blood lymphocytes, and with a shortened time of survival. Monkeys whose lymphocytes produced high levels of virus in culture also had a higher incidence of encephalitis. SIV was more frequently isolated from the brains of animals with encephalitis. No other clear associations were detected.

PMID:
1359149
[Indexed for MEDLINE]

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