Format

Send to

Choose Destination
Trends Biochem Sci. 1992 Aug;17(8):295-9.

The emergence of the chaperone machines.

Author information

1
Département de Biochimie Médicale, Centre Médical Universitaire, Geneve, Switzerland.

Abstract

To ensure proper polypeptide folding, oligomerization and transport, elaborate molecular 'chaperone machines' have evolved. These machines are usually composed of a major chaperone protein that binds promiscuously to nascent, unfolded, misfolded or aggregated polypeptides and a set of chaperone 'cohorts', whose function is to enhance efficiency and ensure recycling. These chaperone machines can function by themselves or synergistically to carry out their various tasks.

PMID:
1357791
DOI:
10.1016/0968-0004(92)90439-g
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center