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Lancet. 1992 Oct 3;340(8823):819-20.

Low-dose inhalation nitric oxide in persistent pulmonary hypertension of the newborn.

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Department of Pediatrics, Children's Hospital, Denver, Colorado 80218-1088.


We studied the effects of inhaled nitric oxide (NO) in 9 newborn infants with severe persistent pulmonary hypertension (PPHN) who were candidates for extracorporeal membrane oxygenation treatment. With low doses of NO (10-20 ppm) all showed rapid improvement in oxygenation without reduction of systemic blood pressure. In 6 infants treated with inhaled NO for 24 h, clinical improvement was sustained at 6 ppm.

[Indexed for MEDLINE]

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