Format

Send to

Choose Destination
Lancet. 1992 Sep 19;340(8821):709-12.

Smoking as "independent" risk factor for suicide: illustration of an artifact from observational epidemiology?

Author information

1
Department of Public Health, University of Glasgow, UK.

Abstract

Two widely used criteria for determining whether an association between a risk factor and a disease is causal are dose response and independence from other factors. Data from a large US risk factor study (MRFIT) throw up a relation between cigarette smoking and suicide that meets these criteria, yet appears to be biologically implausible. It is likely that many more such associations, for other exposures and other diseases, are equally spurious, but are protected by their lack of obvious implausibility.

Comment in

PMID:
1355809
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center