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J Clin Pharm Ther. 1992 Jun;17(3):155-64.

Metabolic effects of beta 2-agonists.

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Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, U.K.


Catecholamines produce a number of biochemical changes most of which result from stimulation of beta 2-receptors. Interest in these metabolic effects has increased recently as a consequence of the concern over the relatively high mortality from acute asthma attacks. In this review the data on the impact of beta 2-agonists on glucose production, insulin release and lipolysis are presented. Thereafter the subject of hypokalaemia, the mechanism for its production by beta 2-agonists and its relevance to cardiac arrhythmias are considered in detail. Finally the fall in plasma magnesium and the possible role of beta 2-agonists in the production of lactic acidosis are discussed.

[Indexed for MEDLINE]

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