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Cell. 1992 Jul 24;70(2):215-23.

H-2M3 presents a Listeria monocytogenes peptide to cytotoxic T lymphocytes.

Author information

1
Howard Hughes Medical Institute, Department of Immunology, Seattle, Washington.

Abstract

We report evidence that a major histocompatibility complex-encoded nonclassic class I molecule presents a foreign peptide to cytotoxic T lymphocytes (CTL) during an infection. Mice immunized with virulent Listeria monocytogenes generate CD8+ CTL with alpha beta receptors specific for a bacterial peptide presented by a conserved class I molecule encoded in the M region of the major histocompatibility complex. The Listeria peptide is digested by carboxypeptidase Y but resists aminopeptidase M, and only peptides with N-formyl methionine competitively block its presentation to CTL. Transfection with the H-2M3d gene enables a negative (H-2w17) cell line to present the bacterial peptide. One function, therefore, of H-2M3 is to present bacterial peptides to CTL during infection.

PMID:
1353418
DOI:
10.1016/0092-8674(92)90097-v
[Indexed for MEDLINE]

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