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Brain Res Mol Brain Res. 1992 May;13(4):359-62.

Dopamine transporter mRNA: dense expression in ventral midbrain neurons.

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Laboratory of Molecular Neurobiology, NIDA, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224.


Oligonucleotides and a full-length cDNA encoding a functional dopamine transporter (DAT1) hybridize to a 3.7 kb mRNA that is concentrated in mRNA prepared from midbrain and absent in specimens from cerebellum or cerebral cortex. In situ hybridization reveals substantial hybridization densities overlying neurons of the substantia nigra, pars compacta, and the parabrachialis pigmentosus region of the ventral tegmental area (VTA). Neurons in the linear and paranigral VTA regions display lower levels of expression. Preliminary studies in arcuate neurons suggest modest hybridization. Different dopaminergic cell groups display different levels of DAT1 dopamine transporter expression.

[Indexed for MEDLINE]

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