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Arthritis Rheum. 1992 Jul;35(7):756-60.

T cell receptor gamma variable gene locus polymorphism in patients with rheumatoid arthritis.

Author information

1
INSERM U291, Montpellier, France.

Abstract

OBJECTIVE:

We sought new susceptibility markers for rheumatoid arthritis (RA) among the T cell receptor gamma (TCR gamma) genes.

METHODS:

We analyzed restriction fragment length polymorphisms (RFLP) of the first variable subgroup of TCR gamma genes in a group of French control subjects and a group of French RA patients.

RESULTS:

No significant difference in Eco RI RFLP was found between the 2 study populations: Allele frequencies were virtually identical. There was no polymorphism using Hind III.

CONCLUSION:

These results exclude TCRV gamma I polymorphism as a disease susceptibility marker in RA.

PMID:
1352450
[Indexed for MEDLINE]

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