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Mov Disord. 1992;7(2):178-80.

Postvaccinal parkinsonism.

Author information

1
Department of Neurology, General Hospital, University of São Paulo Medical School, Brazil.

Abstract

A 5-year-old boy, with a history of fever beginning 15 days after a vaccination for measles, developed a rigid-akinetic syndrome 3 days after the fever began. A spinal tap obtained 1 week after the onset of fever showed pleocytosis with a monocellular pattern. A CT scan of the head and EEG did not disclose any abnormality. An MRI performed 3 months after the event, however, showed clear-cut evidence of bilateral substantia nigra lesions, suggesting secondary gliosis. The response to levodopa was good, but adverse reactions appeared early. The child is now 7 years old. Bromocriptine, deprenyl, and levodopa have produced a remarkable improvement of the parkinsonian features.

Comment in

PMID:
1350062
DOI:
10.1002/mds.870070213
[Indexed for MEDLINE]

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