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J Psychiatry Neurosci. 1992 Mar;17(1):28-30.

Neurotoxicity related to lithium and neuroleptic combinations? A retrospective review.

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  • 1Department of Psychiatry, Medical College of Pennsylvania, Philadelphia 19129.

Abstract

The question of toxic interactions resulting from combinations of lithium and neuroleptic drugs is largely based on anecdotal reports. We replicated the methods of Miller and Menninger (1987) who reported that 27% of manic patients on treatment with lithium and neuroleptics developed toxicity. We found no cases of neurotoxicity as defined in the earlier report. Pharmacologic mechanisms and differences in the clinical findings of the two studies are discussed.

PMID:
1349826
PMCID:
PMC1188382
[PubMed - indexed for MEDLINE]
Free PMC Article
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