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Anticancer Res. 1992 Mar-Apr;12(2):495-9.

A single 24h contact time with adriamycin provokes the emergence of resistant cells expressing the Gp 170 protein.

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Institut Curie, Section de Biologie, Paris, France.


We investigate here, in A549 cells, the influence of a single short (1h) or long (24h) adriamycin (ADR) contact time on the long-term cytotoxicity of the drug and on the emergence of resistant cells. In contrast to a 1 h ADR contact, a 24 h treatment provokes the emergence of resistant cells overexpressing the Gp170 protein and this overexpression is maintained for at least three months without any drug selection pressure.

[Indexed for MEDLINE]

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