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Lancet. 1992 Apr 25;339(8800):1018-9.

Sensitivity of serological assays to identify blood donors with hepatitis C viraemia.

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1
First Department of Pathology, Nihon University School of Medicine, Tokyo, Japan.

Abstract

Blood donors at high risk of hepatitis C virus (HCV) infection were tested for viraemia by the polymerase chain reaction (PCR). PCR results were accepted as positive only if reactive in 3 of 4 tests and if confirmed in an independent laboratory. The sera were also tested by 6 different assays to determine the ability of current serological assays to detect viraemic blood donors. Of 19 PCR-positive sera, only 13 (68%) were detected by the most sensitive of the serological assays. If these results are confirmed, automated PCR assays may be required for blood-donor screening to prevent transmission of HCV.

PMID:
1349053
[Indexed for MEDLINE]
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