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Lancet. 1992 Feb 22;339(8791):458-9.

Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes.

Author information

1
Department of Pathology, University of Florida, Gainesville.

Abstract

Insulin-dependent diabetes is characterised by autoantibodies to several pancreatic-islet-cell antigens, including glutamate decarboxylase. We measured the proliferative responses to this antigen of peripheral-blood mononuclear cells from patients with newly diagnosed insulin-dependent diabetes, relatives of diabetic patients, and healthy controls. The likelihood of a positive response was substantially greater among the diabetic patients and relatives positive for islet-cell autoantibodies (ICA) than among subjects at low risk of diabetes (controls and ICA-negative relatives). Glutamate decarboxylase may have a pathogenetic role in insulin-dependent diabetes.

PMID:
1346821
DOI:
10.1016/0140-6736(92)91061-c
[Indexed for MEDLINE]

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