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Surg Oncol. 1992 Dec;1(6):405-11.

Analysis of ras oncogene mutations in human squamous cell carcinoma of the head and neck.

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Department of Otolaryngology, Hospital Central de Asturias, Oviedo, Spain.


The presence of proto-oncogene mutations at codons 12, 13 and 61 of the Ha-, Ki-, and N-ras in primary head and neck squamous cell carcinoma are analysed in this study. Oncogene ras-specific sequences were amplified by the polymerase chain reaction and probed with mutation specific oligonucleotide probes. Mutations were detected in 8 of 22 samples (36.3%). No mutations were detected on patients' peripheral blood DNA. We found that histologically and clinically, squamous cell carcinomas with or without a ras mutation do not differ significantly from each other.

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