Format

Send to

Choose Destination
Pharmacol Ther. 1992;56(1):23-51.

Calcitonin gene-related peptide: multiple actions, multiple receptors.

Author information

1
Department of Pharmaceutical Sciences, Aston University, Aston Triangle, Birmingham, U.K.

Abstract

Calcitonin gene-related peptide (CGRP) shows diversity both in its effects and its receptors. It is likely to have roles as a neurotransmitter, neuromodulator, local hormone and trophic factor. Its effects include rapid changes in neuronal activity, relaxation of many types of smooth muscle, actions on metabolism and changes in gene expression. Receptor heterogeneity has been revealed from experiments comparing agonist potency ratios and antagonist affinities. The evidence from these approaches is reviewed in this article and a speculative receptor classification scheme is proposed. Some of the likely future directions for CGRP research are discussed.

PMID:
1338400
DOI:
10.1016/0163-7258(92)90036-y
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center