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J Nat Prod. 1992 Dec;55(12):1732-40.

Synergistic effect of flavones and flavonols against herpes simplex virus type 1 in cell culture. Comparison with the antiviral activity of propolis.

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Laboratoire de Pharmacognosie et Mycologie, Faculté de Pharmacie, Université de Rennes I, France.


The in vitro activity against herpes simplex virus type 1 of the major flavonoids identified in propolis was investigated. Flavonols were found to be more active than flavones, the order of importance being galangin, kaempferol, and quercetin. The efficacy against HSV-1 of binary flavone-flavonol combinations has been also investigated. The synergy demonstrated by all combinations could explain why propolis is more active than its individual compounds.

[Indexed for MEDLINE]

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