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Curr Opin Genet Dev. 1992 Dec;2(6):874-82.

Transcriptional regulation and transpositional selection of active SINE sequences.

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Department of Genetics, University of California, Davis 95616.


Alu repeats are short interspersed elements whose transposition has lead to genetic variability and heritable disorders in humans. A select subset of the nearly one million Alu sequences in human DNA actually produce new transpositions. The evolution of newly inserted Alu repeats is currently a key subject for study. Mechanisms of RNA polymerase III activity and the sequence environment into which an Alu inserts might select for transcriptional and posttranscriptional determinants of Alu transposition.

[Indexed for MEDLINE]

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