Format

Send to

Choose Destination
FEBS Lett. 1992 Dec 21;314(3):315-21.

Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

Author information

1
Max-Planck-Unit for Structural Molecular Biology, DESY, Hamburg, Germany.

Abstract

The Alzheimer-like state of tau protein includes phosphorylation by a proline-directed Ser/Thr kinase present in normal or pathological human brain. Extending earlier results on MAP kinase, we show here that the proline-directed kinase, GSK3, can induce an Alzheimer-like immune response involving several distinct and phosphorylatable epitopes at Ser-Pro motifs, as well as a gel mobility shift, similar to MAP kinase. Both kinases behave like microtubule-associated proteins in that they co-purify through cycles of assembly and disassembly, and both kinases are directly associated with paired helical filaments.

PMID:
1334849
DOI:
10.1016/0014-5793(92)81496-9
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center