The low-chloride cough response is not inhibited by a single, high dose of aspirin

R A Stone; P J Barnes; R W Fuller

doi:10.1111/j.1365-2125.1992.tb05645.x

The low-chloride cough response is not inhibited by a single, high dose of aspirin

Br J Clin Pharmacol. 1992 Oct;34(4):370-2. doi: 10.1111/j.1365-2125.1992.tb05645.x.

Authors

R A Stone¹, P J Barnes, R W Fuller

Affiliation

¹ Department of Thoracic Medicine, National Heart and Lung Institute, London.

Abstract

The effect of a single, high dose of aspirin has been assessed against low chloride cough challenge. The drug does not affect the cough response, suggesting that airway prostaglandin generation is not responsible for the tussive activity of low chloride solution.

Publication types

Clinical Trial
Randomized Controlled Trial

MeSH terms

Aspirin / pharmacology*
Bicarbonates
Chlorides* / administration & dosage
Cough / chemically induced
Cough / physiopathology*
Double-Blind Method
Humans
Sodium
Sodium Bicarbonate

Substances

Bicarbonates
Chlorides
Sodium Bicarbonate
Sodium
Aspirin