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Eur J Ophthalmol. 1992 Jul-Sep;2(3):155-7.

Recurrent herpetic keratitis during topical acyclovir application.

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Universit├Ąts-Augenklinik Freiburg, Germany.


Dendritic herpetic keratitis developed in a 49-year-old patient during topical acyclovir treatment. A positive herpes simplex culture was obtained. After acyclovir was replaced by trifluorothymidine and interferon, the dendritic lesion disappeared and herpes simplex culture became negative. Six months later a carcinoma of the larynx was diagnosed. The acyclovir-resistant herpetic keratitis may be associated with the carcinoma because resistant herpes simplex virus strains are predominantly described in patients suffering from immune deficiency.

[Indexed for MEDLINE]

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