CD28 co-stimulation of T-cell-mediated cytotoxicity

M Azuma; J H Phillips; L L Lanier

CD28 co-stimulation of T-cell-mediated cytotoxicity

Int J Cancer Suppl. 1992:7:33-5.

Authors

M Azuma¹, J H Phillips, L L Lanier

Affiliation

¹ Department of Immunology, DNAX Research Institute for Molecular and Cellular Biology, Palo Alto, CA 94304.

PMID: 1330948

Abstract

Co-stimulation via the CD28 pathway permits small, resting human peripheral-blood T lymphocytes to mediate anti-CD3 monoclonal antibody (MAb) "re-directed" cytotoxicity. The effector cells are contained with the "memory" population of T lymphocytes, identified by expression of the CD45RO differentiation antigen. In this article, we review the requirements for initiating a cytolytic response and speculate on the physiological consequences of this process.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antibodies, Monoclonal / immunology
Antigens, CD / immunology*
Antigens, Differentiation, T-Lymphocyte / immunology*
CD28 Antigens
CD3 Complex / immunology*
Cytotoxicity, Immunologic*
Humans
Mast-Cell Sarcoma
Mice
Receptors, Cell Surface / immunology
T-Lymphocytes / immunology*
Tumor Cells, Cultured

Substances

Antibodies, Monoclonal
Antigens, CD
Antigens, Differentiation, T-Lymphocyte
CD28 Antigens
CD3 Complex
Receptors, Cell Surface