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Genitourin Med. 1992 Oct;68(5):325-7.

A double blind study of single dose azithromycin and doxycycline in the treatment of chlamydial urethritis in males.

Author information

1
Department of Dermatovenerology, University of Bergen, Norway.

Abstract

OBJECTIVE:

To compare the efficacy and safety of azithromycin and doxycycline in the treatment of males with uncomplicated urethritis caused by chlamydia trachomatis.

DESIGN:

A multicentre, double-blind, randomised treatment study.

SUBJECTS:

130 male outpatients with clinical signs and symptoms of urethritis.

SETTING:

STD clinics at four Norwegian University Hospitals.

METHODS:

Patients were randomly allocated to 1000 mg azithromycin as single dose or doxycycline 100 mg twice daily for 7 days. Clinical, bacteriological and safety assessments were made at entry and after 1 and 2 weeks. Safety data were also repeated after 4 weeks.

RESULTS:

Demographic data were similar in both groups. At the week 1 assessment bacteriological eradication was achieved in 44 of 44 evaluable azithromycintreated patients and in 42 of 42 in the doxycycline group. At the week 2 assessment the corresponding figures were 35 of 35 and 34 of 34 respectively.

CONCLUSION:

Azithromycin 1000 mg single dose was as effective as doxycycline 100 mg twice daily for 7 days in male patients with chlamydial urethritis.

PMID:
1330880
PMCID:
PMC1195989
DOI:
10.1136/sti.68.5.325
[Indexed for MEDLINE]
Free PMC Article

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