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Clin Neuropharmacol. 1992 Oct;15(5):375-80.

Clinical and pharmacokinetic effects of a diet rich in insoluble fiber on Parkinson disease.

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Service of Neurology, Jiménez Díaz Foundation, Madrid, Spain.


In this study, the effects of a diet rich in insoluble fiber (DRIF) on motor disability and the peripheral pharmacokinetics of orally administered L-dopa in Parkinsonian patients with marked constipation are analyzed. We found a useful effect of a DRIF on plasma L-dopa concentration and motor function. The greatest effect on the plasma L-dopa levels was found early (at 30 and 60 min) after oral administration. There was a relationship between the improvement of constipation and the higher bioavailability of L-dopa. DRIF can be a coadjuvant treatment in patients with Parkinson's disease.

[Indexed for MEDLINE]

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