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J Neurol Neurosurg Psychiatry. 1992 Sep;55(9):844-5.

Botulinum toxin therapy: distant effects on neuromuscular transmission and autonomic nervous system.

Author information

1
Institute of Neurological and Neurosurgical Sciences, University of Messina, Italy.

Abstract

To evaluate distant effects of botulinum toxin, single fibre electromyography on the extensor digitorum communis muscle and six tests of cardiovascular reflexes were performed in five patients injected with BoTox (Oculinum(R) 20-130 units) for craniocervical dystonia and hemifacial spasm. Patients underwent two sessions of treatment and the second time the dosage was doubled. Botulinum toxin injection induced an increase of mean jitter value above normal limits in all cases. An increase of fibre density was recorded six weeks after the treatment. Cardiovascular reflexes showed mild abnormalities in four patients. The data confirm distant effects of botulinum toxin on neuromuscular transmission and on autonomic function.

PMID:
1328540
PMCID:
PMC1015114
[Indexed for MEDLINE]
Free PMC Article

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