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Biochem Biophys Res Commun. 1992 Aug 31;187(1):158-63.

Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2.

Author information

1
Johns Hopkins University School of Medicine, Department of Neuroscience, Baltimore, MD 21205.

Abstract

To clarify the function of the receptor binding protein for inositol hexakisphosphate (IP6), we obtained a partial amino acid sequence from the purified protein and a partial nucleotide sequence from a cDNA clone of the gene. The sequences are essentially identical to those of the alpha-subunit of the clathrin assembly protein AP-2. The IP6 receptor protein analyzed by SDS-PAGE contains a series of subunits which are the same as those of AP-2. Antibodies to AP-2 react with the IP6 receptor protein in immunoblot analysis.

PMID:
1325787
DOI:
10.1016/s0006-291x(05)81473-1
[Indexed for MEDLINE]

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