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Ann Neurol. 1992 Jun;31(6):680-3.

Immunological detection of glutamate receptor subtypes in human central nervous system.

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Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.


Glutamate receptors are the principal excitatory neurotransmitter receptors in the central nervous system and are involved in a number of normal and pathological neuronal processes. Using subunit-specific antipeptide antibodies developed against the predicted amino acid sequences of several rat glutamate receptor cDNAs, we have identified these proteins in post-mortem human central nervous system tissue. Immunoblotting of dissected brain regions demonstrates that these receptor proteins are differentially distributed. The ability to identify these proteins in post-mortem human tissues should allow examination of the changes in levels of receptor subtypes that occur in a variety of neurological and psychiatric diseases.

[Indexed for MEDLINE]

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