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Immunol Today. 1992 Aug;13(8):315-22.

Regulation of TCR alpha and beta gene allelic exclusion during T-cell development.

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Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, France.


Early in their development, most T cells become committed to the expression of one, and only one, TCR alpha beta combination. How do T cells achieve this TCR allelic exclusion? This article discusses the configuration and expression of TCR alpha and beta genes in mature T-cell lines and TCR alpha beta transgenic mice, and proposes three nonexclusive models to account for the significant occurrence of T cells with two productive alpha gene rearrangements.

[Indexed for MEDLINE]

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