Format

Send to

Choose Destination
Immunol Today. 1992 Aug;13(8):315-22.

Regulation of TCR alpha and beta gene allelic exclusion during T-cell development.

Author information

1
Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, France.

Abstract

Early in their development, most T cells become committed to the expression of one, and only one, TCR alpha beta combination. How do T cells achieve this TCR allelic exclusion? This article discusses the configuration and expression of TCR alpha and beta genes in mature T-cell lines and TCR alpha beta transgenic mice, and proposes three nonexclusive models to account for the significant occurrence of T cells with two productive alpha gene rearrangements.

PMID:
1324691
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center