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Eur J Pharmacol. 1992 Apr 10;225(4):355-6.

A newly found angiotensin II receptor subtype mediates cyclic GMP formation in differentiated Neuro-2A cells.

Author information

1
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.

Abstract

In search of the functional role of the newly found angiotensin II (Ang II) binding site which is expressed in differentiated Neuro-2A cells, we found that Ang II causes a marked stimulation of cGMP formation dose-dependently. The stimulation was blocked by the nonselective Ang II receptor antagonist [Sar1,Ile8]Ang II but not by the AT1 antagonist DuP 753 or the AT2 antagonist PD 123319. These results suggest that Ang II increased cGMP level via a new Ang II receptor subtype in differentiated Neuro-2A cells.

PMID:
1323479
DOI:
10.1016/0922-4106(92)90111-8
[Indexed for MEDLINE]

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