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J Infect Dis. 1992 Aug;166 Suppl 1:S7-12.

Intracellular synthesis of varicella-zoster virus.

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Department of Pediatrics, University of Iowa, College of Medicine, Iowa City.


Varicella-zoster virus, a reclusive alpha-herpesvirus, can be isolated and propagated in a limited number of human cell lines. Under in vitro conditions, the virus is strongly cell-associated and, therefore, difficult to recover in a truly cell-free state. The general replication cycle includes the three phases called immediate early, early, and late. An example of an early viral protein is a putative protein kinase called open reading frame (ORF) 47. An example of a late protein is the preponderant viral glycoprotein (ORF 68) designated VZV gpI.

[Indexed for MEDLINE]

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