Format

Send to

Choose Destination
Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5266-70.

Rapid evolution of the human gene for cytochrome c oxidase subunit IV.

Author information

1
Department of Anatomy and Cell Biology, University of Michigan Medical School, Ann Arbor 48109.

Abstract

We have compared the DNA sequences of nine mammalian genes for cytochrome c oxidase subunit IV (COX4 genes)--four expressed genes (human, bovine, rat, and mouse) and five pseudogenes (human, chimpanzee, orangutan, squirrel monkey, and bovine)--and constructed the sequence of the ancestral mammalian COX4 gene. By analyzing these sequences to determine the pattern and rate of nucleotide substitution in each branch of the evolutionary tree, we deduced that the human gene has evolved rapidly since the origin of the primate pseudogene approximately 41 million years ago, and we discuss the suggestion that this results from coevolution of nuclear and mitochondrial genes for cytochrome c oxidase.

PMID:
1319058
PMCID:
PMC49272
DOI:
10.1073/pnas.89.12.5266
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center