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Virus Res. 1992 Apr;23(1-2):135-50.

Expression of the gene coding for the major outer capsid protein of SA-11 rotavirus in a baculovirus system.

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Department of Corporate Molecular Biology, Abbott Laboratories, North Chicago, IL.


The gene coding for the major outer capsid protein (VP7) of simian rotavirus SA-11 has been expressed in a baculovirus-insect cell system. The resulting protein is 35 kDa and is primarily associated with the endoplasmic reticulum. Neutralizing SA-11 polyclonal antiserum and VP7 monospecific antiserum reacted specifically with the expressed gene product. Antiserum derived against the recombinant VP7 protein neutralized SA-11 rotavirus infectivity in a fluorescent focus assay.

[Indexed for MEDLINE]

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