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Cancer Lett. 1992 May 30;64(1):11-5.

Early activation of the proto-oncogene c-fgr during Epstein-Barr virus immortalization.

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Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-3135.


In an attempt to clarify the chronological relationships between Epstein-Barr virus (EBV) infection, B cell immortalization and c-fgr activation, we evaluated for the presence of EBV-determined nuclear antigen (EBNA), cellular DNA synthesis and expression of c-fgr-specific RNA following infection of human peripheral blood lymphocytes with B95-8 EBV. High expression of c-fgr was observed prior to EBNA detection and cellular DNA synthesis in EBV-infected cells. These results suggest that activation of c-fgr is an essential event during the early phase of EBV immortalization.

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