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J Nat Prod. 1992 Mar;55(3):380-4.

Akuammine and dihydroakuammine, two indolomonoterpene alkaloids displaying affinity for opioid receptors.

Author information

1
Laboratoire de Chimie des Substances Thérapeutiques Naturelles, Centre d'Etudes Pharmaceutiques, Châtenay-Malabry, France.

Abstract

Akuammine [1], an indolomonoterpene alkaloid, which is the major component of the seeds of Picralima nitida, was reduced to dihydroakuammine [4]. This compound has structural analogy with eseroline [7], for which affinity for opiate receptors was reported. The present investigation showed that 1 and 4 also bind (with lower affinity however) to mu and kappa opiate receptors. 1H- and 13C-nmr spectra of 1 and 4 have been fully assigned by 2D nmr experiments.

PMID:
1317407
[Indexed for MEDLINE]

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