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FEBS Lett. 1992 May 25;303(1):53-8.

Differential expression of two sodium channel subtypes in human brain.

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  • 1Department of Psychiatry, University of Alabama, Birmingham 35294.


Two partial human brain sodium channel cDNA sequences (designated HBSC I and II) have been cloned and mapped to chromosome 2q23-2q24 by chromosome microdissection-PCR (CMPCR). The distribution of HBSC I and II mRNA in human brain was studied by means of a novel approach based on the ligase detection reaction. These studies demonstrate that HBSC I and II mRNA is heterogeneously distributed in brain, and that the relative ratio of the two forms can vary as much as 7-fold between different regions.

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