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Cell. 1992 May 15;69(4):669-76.

Drosophila retinal degeneration C (rdgC) encodes a novel serine/threonine protein phosphatase.

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Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892.


The Drosophila retinal degeneration C (rdgC) gene is required to prevent light-induced retinal degeneration. Molecular analysis shows that the rdgC transcription unit encodes a novel serine/threonine protein phosphatase. Amino acids 153-393 define a domain that has 30% identity with the catalytic domains of types 1, 2A, and 2B serine/threonine protein phosphatases. A putative regulatory domain is appended that contains multiple potential Ca(2+)-binding sites or "EF hand motifs." Thus, the analysis suggests that the rdgC protein is a novel type of serine/threonine protein phosphatase that is directly regulated by Ca2+. rdgC is expressed in the visual systems of the fly, as well as in the mushroom bodies of the central brain.

[Indexed for MEDLINE]

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