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Neurosci Lett. 1992 Mar 30;137(2):241-4.

Sources and targets of nitric oxide in rat cerebellum.

Author information

1
Department of Physiology, University of Liverpool, UK.

Abstract

Nitric oxide (NO) mediates cell-cell signalling in the brain and stimulates cyclic GMP (cGMP) production in target cells. We have used NADPH-diaphorase (reduced nicotinamide adenine dinucleotide phosphate-diaphorase) histochemistry to identify NO-producing neurones and cGMP immunohistochemistry to locate the targets of NO in rat cerebellum. NADPH-diaphorase staining was prominent in granule cells and in the molecular layer. cGMP immunostaining in cerebellar slices stimulated with the NO donors, nitroprusside and SIN-1, was found in granule cells, glomeruli, fibres, Bergmann glia and in other astrocytes. The results provide visible evidence that NO mediates neuron-neuron and neuron-glia communication.

PMID:
1316590
DOI:
10.1016/0304-3940(92)90413-2
[Indexed for MEDLINE]

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